Viral infection, inflammation and schizophrenia
نویسندگان
چکیده
منابع مشابه
Schizophrenia, Inflammation and Toxoplasma gondii Infection
Genetic analysis suggests that schizophrenia is a polygenetic disease, mostly consisting of common mutations with low risk and rare mutations with higher risks [1]. Although data suggests a strong genetic component to the risk of developing schizophrenia, environmental and/or developmental risk factors also contribute. Currently, there are no interventions that target and mitigate the effects o...
متن کاملInfection and inflammation in schizophrenia and bipolar disorder.
The present study investigated the relationship between exposure to infectious agents and inflammation markers in individuals with schizophrenia (SZ), bipolar disorder (BP), and controls without a psychiatric disorder. We measured plasma levels of antibodies and innate immune markers and correlated them with clinical symptoms and cognitive function. In both SZ and BP, we found an increase in so...
متن کاملThe immunoproteasome and viral infection: a complex regulator of inflammation
During viral infection, proper regulation of immune responses is necessary to ensure successful viral clearance with minimal host tissue damage. Proteasomes play a crucial role in the generation of antigenic peptides for presentation on MHC class I molecules, and thus activation of CD8 T cells, as well as activation of the NF-κB pathway. A specialized type of proteasome called the immunoproteas...
متن کاملInflammation and schizophrenia.
Inflammation is one of the body’s first lines of defense in response to injury or infection, and increased inflammation is found in many diseases. Acute inflammation is a nonspecific response characterized by warmth, pain, and swelling. Leukocytes migrate to the area of injury and become activated, the blood supply to the area increases, and blood vessels become more permeable, allowing cells a...
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ژورنال
عنوان ژورنال: Progress in Neuro-Psychopharmacology and Biological Psychiatry
سال: 2013
ISSN: 0278-5846
DOI: 10.1016/j.pnpbp.2012.02.001